Interview: James C. Harris, MD - Part 1 of 2

Director, Developmental Neuropsychiatry Clinic
Professor of Psychiatry & Behavioral Sciences & Professor of Pediatrics Johns Hopkins School of Medicine

By Bruce Hershfield, MD

[Fall 2007; Vol. 34, No. 1; Pg 6]

Q: “Please tell us about the Agnes Purcell McGavin Award that the APA gave you in San Diego.”

A: “The award is for “distinguished career service”. It is a lifetime achievement award. The areas that were highlighted included my textbook, published in 1995 “Developmental Neuropsychiatry”. It is a single-authored two-volume textbook that is the culmination of 25 years and more of working with children and adolescents with developmental disabilities.  I wanted to write it a textbook from a developmental perspective. I wanted to explain how understanding neurogenetic disorders that involved brain function could help us better understand how brain systems emerge and perhaps help us also understand the neurological basis of obsessive compulsive disorder, compulsive self-injury, and other types of behaviors.

I also received the award because of my activities in residency education, as President of the Society of Professors of Child & Adolescent Psychiatry, which is the organization that represents the various academic divisions in child & adolescent psychiatry, as President of the Maryland Regional Council of Child and Adolescent Psychiatry,  and my involvement with the American College of Neuropsychopharmacology and the Society for Neuroscience.”

Q: “You’ve been working in neurodevelopment for quite some time.”

A.: “Since 1976.  When I finished my residency in Adult & Child Psychiatry, I was made Director of Psychiatry at the Kennedy Krieger Institute. Later I directed the Division of Child Psychiatry at Hopkins for four years and combined the Kennedy Krieger program and the Hopkins program into one program in Child and Adolescent Psychiatry.  After Joe Coyle followed me as the Division Director in 1982, I continued to direct the training program in Child and Adolescent Psychiatry, During that time I basically had two hats. One was to direct the training program. (We had NIMH funding training most of those years.) The other hat was to direct the developmental neuropsychiatry program, as we started to call it, at Kennedy Krieger. Eventually, it seemed to me that there was not enough emphasis within Psychiatry on neurodevelopment. I was granted a Sabbatical to write a textbook, which I hoped would emphasize a developmental approach and eventually lead to a subspecialty area within Psychiatry.”

Q: “Is that the way it turned out?”

A: “There isn’t a subspecialty “per se”, but it is considered to be a area of special focus within Psychiatry and reviewers suggested that my textbook could pave the way for an eventual specialty area.  The developmental pediatricians were seeing these many of children at the time the book was written, but they weren’t emphasizing their behavioral and emotional needs. Surprisingly Developmental Neuropsychiatry was chosen “Medical Book of the Year” out of 2500 books in 76 medical specialties in the year of its publication.  When I received the book of the year citation I was told that the decision was made because of my focus on a new specialty area within Psychiatry.”

Q: “Are you communicating with colleagues in the field and are there other indications that it is becoming a new specialty?”

A: “I think that is happening incrementally as with the greater focus on clinical neuroscience in psychiatry and ongoing efforts to understand the neurobiology in of different types of  psychiatric disorders in children.  I focused on neurodevelopmental and neurogenetic disorders, but other investigators are now looking at brain function in bipolar disorder and OCD and other conditions.

My NIH funded research has focused on brain mechanisms in Lesch-Nyhan syndrome.  That‘s a rare genetic disorder, but practically everyone knows it because of the characteristic severe compulsive self-injury.  We did the first PET scans to try to understand the role of the dopamine and the serotonin systems in self-injurious behavior. Since then, in looking at those mechanisms, I’ve been interested as well in self-injury in eating disorders and particularly in bulimia nervosa. 

The outcome of continued focus on neurodevelopment is that having done the book on developmental neuropsychiatry, I wrote another book, published in 2006, that’s called “Intellectual Disability”.  The reason I wrote it was that it had become increasingly clear that “mental retardation” was a stigmatizing term.  By writing a textbook, I’d hoped to focus attention on a new name, which is increasingly being adopted “intellectual disability”. In 2007 the American Association on Mental Retardation changed its name to the American Association of Intellectual & Developmental Disabilities.  So I think that we’re moving forward and that this is will be the accepted diagnostic term in DSM-V.”

To Be Continued in Next Edition