A Half Century of Change in Psychiatry

By Gerald D. Klee, M.D.

[Winter 2003; Vol. 29, No. 2; Pg 3, 15]

Last spring I attended the 50th Anniversary celebration of my Harvard Medical School Class. My generation grew up in a badly battered world. We hoped to leave it in better condition than we found it. The following comments summarize some of my views about how psychiatry evolved into its present state. I believe that most of my classmates share my views.

Life has been good to most of us. Our careers spanned the golden age of medicine, when scientific progress grew rapidly and there was little interference in our relationships with patients by outside agents. We experienced the Great Depression and World War II and entered medical school, where we would get an education that we hoped would help us save the world. Like me, most of my classmates had the benefit of having their tuition of $800 a year paid for by the GI Bill. Tuition now is about forty times that (4000%), about the same rate of inflation as for a hospital bed. Compared to tuition and health care, the general inflation rate during the half century is modest, a mere 700% or so, according to the Consumer Price Index.

At the time of our graduation, no one could have foreseen the extraordinary increase in medical costs to come, nor how the healthcare system would be hijacked by clever business people who make fortunes by denying treatment and pocketing one third or more of the money meant to pay for medical care. And who would have believed that a time would come when a doctor’s time and interest in patients would be treated as valueless?

At Harvard, as elsewhere, there is much more for students to learn in medical school than ever before. Information technology makes the process more efficient and virtual patients provide ingenious ways for students to deal with realistically simulated clinical situations. However, access to actual patients has decreased under managed care, which won’t allow attending physicians to delegate responsibility for patients. This deprives residents and students of valuable patient contact. Psychiatric trainees are further deprived of patient contact by the reduction or elimination of hospital beds in many institutions. Hospital stays are shorter, commonly three days, which gives attendings and trainees little chance to get to know patients, let alone learn enough about them to make accurate diagnoses, or to treat them effectively. Thus, trainees learn a badly flawed model of treatment, which they eventually carry into their practices under managed care.

When I entered residency, neuroscience was primitive and psychotherapy was the most widely recognized form of psychiatric treatment. I saw a stunning change beginning in 1954 when chlorpromazine brought chronic schizophrenic patients into remission by the thousands. This was the beginning of the psychopharmacology revolution that changed how we think about and treat patients with mental illnesses. Drugs have become so important that there’s a tendency to forget about psychotherapy, which is a big mistake.

In less than half a century, neuroscientists have discovered most of what is now known about the brain. Fifty years ago, acetylcholine was the only known neurotransmitter in the brain. Now we know of numerous transmitters and receptors and how various drugs affect them.

The application of psychopharmacology has its good and bad sides. On the positive side, it has led to better drugs and better treatment, but all too frequently drugs are the only treatment patients get. Worse yet is the fact that psychiatrists doing "med checks" seldom have enough time with their patients to prescribe wisely. Still worse, those prescribing the drugs are most often untrained in psychiatry. Throughout my career, it has been the psychiatrist's role to integrate physical and mental care, psychotherapy and pharmacology. Thanks to managed care, the psychiatrist is now supposed to be no more than a pill pusher. That model is a major cause of medical errors and rising costs.

I’m told that up to 80% of patients admitted to inpatient psychiatric services in Baltimore have problems with illicit drugs and/or alcohol in addition to their psychiatric diagnoses. They are usually put on prescription drugs and are back on the street within a few days, with no treatment for chemical dependency. This is partly due to the Medicaid reimbursement system, which splits treatment for diagnoses of chemical dependency and mental illness and doesn’t pay enough for either.

Science and technology grow exponentially, but human wisdom grows little, if at all and old wisdom is often forgotten. A well known consequence is that discoveries in science and technology are often put to wrong or even harmful uses. Dynamite is an example of a discovery being put to unintended uses. It was invented by Alfred Nobel for use in construction projects. An ardent pacifist, Nobel thought his invention would put an end to war by making it so horrible that no one would want to engage in it. Of course he was disappointed. The scientists who created the foundations of modern psychopharmacology must be equally disappointed by the misuse of their discoveries.

In the 1960s, LSD guru Timothy Leary and many of his hippie followers shared a belief that all human problems can be solved by recklessly taking drugs. Their slogan, Better Living Through Chemistry, was borrowed from the chemical giant DuPont, a maker of dynamite. Often, the drugs Leary promoted turned out to be dynamite for those who used them.

Over time, diverse streams have ways of merging to produce unexpected consequences. Take the sixties drug culture, blend it with the pharmaceutical industry’s need for constantly expanding markets and profits, add managed care’s voracious drive to profit by quick fixes for complicated psychiatric illnesses. Stir the pot and Presto! Psychotropic drugs are a cure for all life’s problems.

We hoped we would leave the world in better condition than we found it, but I’ve begun to feel pessimistic. I wonder if there’s a pill for that.

Doctor Klee is a Life Fellow Emeritus of the American College of Neuropsychopharmacology.